Simon A Jones Selected Research

Sebelipase alfa

3/2021	Correction to: Long-term survival with sebelipase alfa enzyme replacement therapy in infants with rapidly progressive lysosomal acid lipase deficiency: final results from 2 open-label studies.
1/2021	Long-term survival with sebelipase alfa enzyme replacement therapy in infants with rapidly progressive lysosomal acid lipase deficiency: final results from 2 open-label studies.
1/2017	Survival in infants treated with sebelipase Alfa for lysosomal acid lipase deficiency: an open-label, multicenter, dose-escalation study.
11/2014	Sebelipase alfa over 52 weeks reduces serum transaminases, liver volume and improves serum lipids in patients with lysosomal acid lipase deficiency.

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Simon A Jones Research Topics

Disease

35	Inflammation (Inflammations) 01/2023 - 08/2003
20	Mucopolysaccharidoses 04/2022 - 01/2011
15	Mucopolysaccharidosis I (Hurler Syndrome) 10/2022 - 08/2011
15	Arthritis (Polyarthritis) 01/2021 - 09/2003
11	Mucopolysaccharidosis II (Hunter Syndrome) 11/2023 - 10/2010
10	Infections 04/2024 - 11/2002
9	Rheumatoid Arthritis 01/2020 - 05/2005
8	Niemann-Pick Diseases (Niemann Pick Disease) 03/2023 - 09/2015
7	Peritonitis 01/2023 - 11/2002
7	Mucopolysaccharidosis III (Sanfilippo Syndrome) 12/2021 - 01/2011
7	Neoplasms (Cancer) 12/2018 - 04/2005
6	Wolman Disease (Wolman's Disease) 01/2023 - 11/2014
5	Disease Progression 01/2018 - 08/2008
4	Glycogen Storage Disease Type II (Pompe's Disease) 06/2023 - 01/2012
4	Fibrosis (Cirrhosis) 01/2023 - 01/2014
4	COVID-19 01/2022 - 01/2020
4	Experimental Arthritis 01/2021 - 09/2003
4	Chronic Disease (Chronic Diseases) 12/2018 - 09/2005
3	Mucopolysaccharidosis VI (Syndrome, Maroteaux-Lamy) 06/2023 - 08/2014
3	Lysosomal Storage Diseases (Lysosomal Storage Disease) 04/2022 - 02/2015
3	Gaucher Disease (Gaucher's Disease) 01/2022 - 12/2020
3	Neurologic Manifestations (Neurological Manifestations) 01/2022 - 01/2016
3	Neurodegenerative Diseases (Neurodegenerative Disease) 06/2015 - 01/2011
3	Human Influenza (Influenza) 10/2013 - 02/2008
3	Neuroinflammatory Diseases 10/2013 - 01/2012
2	Fever (Fevers) 04/2024 - 01/2017
2	Hemorrhage 04/2024 - 09/2020
2	Persistent Infection 07/2023 - 12/2018
2	Renal Insufficiency (Renal Failure) 01/2023 - 01/2018
2	Type 2 Diabetes Mellitus (MODY) 01/2023 - 11/2017
2	Necrosis 01/2023 - 01/2021
2	Splenomegaly 12/2022 - 09/2020
2	Cognitive Dysfunction 09/2022 - 09/2022
2	Type C Niemann-Pick Disease (Niemann Pick Disease, Type C) 03/2022 - 01/2018
2	Autoimmune Diseases (Autoimmune Disease) 01/2021 - 08/2014
2	Critical Illness (Critically Ill) 12/2020 - 05/2020
2	Metabolic Diseases (Metabolic Disease) 01/2020 - 05/2019
2	Mucopolysaccharidosis VII (Sly Syndrome) 05/2019 - 01/2019
2	Sleep Wake Disorders 01/2019 - 01/2019
2	Dysostoses 01/2019 - 03/2016
2	Mucopolysaccharidosis IV (Morquio Syndrome) 01/2019 - 03/2018
2	Mitochondrial Diseases (Mitochondrial Disease) 12/2016 - 10/2016
2	Hip Dislocation 03/2016 - 10/2013
2	Tertiary Lymphoid Structures 02/2016 - 10/2015
2	Lung Diseases (Lung Disease) 09/2015 - 07/2010

Drug/Important Bio-Agent (IBA)

33	Interleukin-6 (Interleukin 6)IBA 01/2023 - 08/2003
22	CytokinesIBA 01/2023 - 08/2003
16	EnzymesIBA 06/2023 - 01/2011
10	Proteins (Proteins, Gene)FDA Link 10/2022 - 08/2003
10	Interleukin-6 Receptors (Interleukin 6 Receptor)IBA 11/2014 - 09/2003
9	GlycosaminoglycansIBA 04/2022 - 08/2011
9	AntigensIBA 12/2018 - 05/2006
8	idursulfase FDA Link 11/2023 - 10/2010
8	LipidsIBA 01/2023 - 08/2009
7	olipudase alfaIBA 03/2023 - 09/2015
7	ChemokinesIBA 11/2016 - 05/2004
5	InterleukinsIBA 07/2023 - 01/2011
5	Biomarkers (Surrogate Marker)IBA 01/2021 - 02/2015
4	AcidsIBA 12/2022 - 01/2012
4	Sebelipase alfaIBA 03/2021 - 11/2014
4	AntibodiesIBA 06/2019 - 05/2006
4	human GALNS proteinIBA 01/2018 - 11/2014
4	Interleukin-10 (Interleukin 10)IBA 06/2016 - 08/2014
4	Cytokine Receptor gp130IBA 01/2011 - 09/2003
3	Anti-Bacterial Agents (Antibiotics)IBA 04/2024 - 11/2014
3	N-Acetylgalactosamine-4-Sulfatase (Arylsulfatase B)IBA 06/2023 - 08/2014
3	C-Reactive ProteinIBA 01/2023 - 09/2014
3	Sphingomyelin Phosphodiesterase (Sphingomyelinase)IBA 12/2022 - 09/2015
3	Iduronidase (alpha-L-Iduronidase)IBA 10/2022 - 10/2015
3	Interleukin-27 (Interleukin 27)IBA 01/2020 - 10/2015
3	Matrix Metalloproteinases (MMPs)IBA 01/2014 - 01/2002
3	N-sulfoglucosamine sulfohydrolase (sulfamidase)IBA 10/2013 - 01/2011
2	Triglycerides (Triacylglycerol)IBA 01/2023 - 11/2014
2	LigandsIBA 01/2023 - 12/2011
2	Interleukin-1 Receptors (Interleukin 1 Receptor)IBA 01/2023 - 11/2014
2	LDL CholesterolIBA 01/2023 - 01/2021
2	Insulin (Novolin)FDA Link 01/2023 - 11/2017
2	Macrophage Colony-Stimulating FactorIBA 01/2023 - 01/2013
2	CholesterolIBA 01/2023 - 01/2018
2	Lysergic Acid Diethylamide (LSD)IBA 01/2022 - 01/2019
2	Glucosylceramidase (Glucocerebrosidase)IBA 01/2022 - 12/2020
2	heparan sulfate sulfataseIBA 12/2021 - 01/2016
2	neodymium pyrocatechin disulfonate (NPD)IBA 01/2021 - 09/2015
2	Interleukin-17 (Interleukin 17)IBA 01/2020 - 10/2011
2	InterferonsIBA 01/2020 - 01/2014
2	vestronidase alfaIBA 05/2019 - 01/2019
2	human GAA protein (Myozyme)FDA Link 07/2017 - 01/2012
2	Antiviral Agents (Antivirals)IBA 04/2017 - 04/2014
2	Mitochondrial DNA (mtDNA)IBA 12/2016 - 10/2016
2	SphingomyelinsIBA 01/2016 - 09/2015

Therapy/Procedure

33	Enzyme Replacement Therapy 03/2023 - 10/2010
21	Therapeutics 01/2022 - 01/2002
10	Hematopoietic Stem Cell Transplantation 01/2022 - 08/2011
4	Peritoneal Dialysis 01/2023 - 12/2011
4	Cell Transplantation 01/2023 - 03/2015
4	Stem Cell Transplantation 01/2022 - 03/2016
3	Artificial Respiration (Mechanical Ventilation) 12/2020 - 01/2011
2	Biological Therapy 01/2022 - 03/2013
2	Transplantation 01/2022 - 02/2016
2	Mechanical Ventilators (Ventilator) 10/2016 - 01/2011